Best User Interface
I've been playing Civ V with the standard User Interface for over year now with full animations.
However, I tried a change today and I am awed. I changed to the following UI instead:
Use Strategic View.
Toggle MapOptions: Icon Mode shows All; ShowFeatures; Show Fog of War; Hex Grid. Have Active Overlay show Resources.
The old way I used to start getting dizzy after 2 hours of playing straight. Now I can go up to 6 hours and not notice any problems. I can see everything in every revealed hex with the colors different for each hex with a different class of resources. One can even show trade routes highlighted in yellow with a slight change.
In fact, this UI reminds me of the old board games produced by Avalon Hill but they are now in a PC.
I'm posting this to give others a clue if they are locked into the standard UI with the animations. Try it and it will be like playing a different game.